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Don Tillman, professor of genetics, has never been on a second date. He is a man who can count all his friends on the fingers of one hand, whose lifelong difficulty with social rituals has convinced him that he is simply not wired for romance. So when an acquaintance informs him that he would make a "wonderful" husband, his first reaction is shock. Yet he must concede to the statistical probability that there is someone for everyone, and he embarks...

"The Wife Project is complete, and Don and Rosie are happily married and living in New York. But they're about to face a new challenge because--surprise--Rosie is pregnant. Don sets about learning the protocols of becoming a father, but his unusual research style gets him into trouble with the law. Fortunately his best friend Gene is on hand to offer advice: he's left Claudia and moved in with Don and Rosie. As Don tries to schedule time for pregnancy...

MEET DON TILLMAN, a brilliant yet socially challenged professor of genetics, who' s decided it' s time he found a wife. And so, in the orderly, evidence-based manner with which Don approaches all things, he designs the Wife Project to find his perfect partner: a sixteen-page, scientifically valid survey to filter out the drinkers, the smokers, the late arrivers. Rosie Jarman is all these things. She also is strangely beguiling, fiery, and intelligent.

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Don Tillman, a profesor of genetics, sets up a project designed to find him the perfect wife, starting with a questionnaire that has to be adjusted a little as he goes along. Then he meets Rosie, who is everything he's not looking for in a wife, but she ends up his friend as he helps her try and find her biological father.